Looking for expert MLB player prop predictions for Sep 22, 2026? Our AI breaks down the key data from the Red Sox vs Guardians matchup so you can make smarter picks today.
In this MLB game, the Red Sox are listed as the favorites with a -128 Moneyline, which gives them an implied 56.14% chance to win.
Red Sox Preview:
Here are some recent trends for the pitcher:
- Payton Tolle has averaged 7.9 Strikeouts over his last 10 starts.
- Payton Tolle has averaged 1.9 Earned Runs over his last 10 starts.
These players have been hitting the ball well recently:
- Trevor Story has gotten a hit in 10 of his last 10 games (hit his line in 100% of 10 games)
- Caleb Durbin has gotten a hit in 8 of his last 10 games (hit his line in 80% of 10 games)
- Roman Anthony has gotten a hit in 8 of his last 10 games (hit his line in 80% of 10 games)
The player with the highest projected chance at a Home Run is:
- Wilyer Abreu has a 0.16 Home Run projection
Guardians Preview:
Here are some recent trends for the pitcher:
- Parker Messick has averaged 7 Strikeouts over his last 10 starts.
- Parker Messick has averaged 1.6 Earned Runs over his last 10 starts.
These players have been hitting the ball well recently:
- Jo Adell has gotten a hit in 9 of his last 10 games (hit his line in 90% of 10 games)
- Steven Kwan has gotten a hit in 8 of his last 10 games (hit his line in 80% of 10 games)
- Angel Martinez has gotten a hit in 7 of his last 10 games (hit his line in 70% of 10 games)
The player with the highest projected chance at a Home Run is:
- Angel Martinez has a 0.24 Home Run projection
Roster Outlook
| Red Sox | Guardians |
|---|---|
| Projected Pitcher | Projected Pitcher |
| Payton Tolle | Parker Messick |
| Projected Roster | Projected Roster |
|
|
Red Sox
| Projected Pitcher |
| Payton Tolle |
| Projected Roster |
|
Guardians
| Projected Pitcher |
| Parker Messick |
| Projected Roster |
|
Recent Form
Red Sox
Last 5 Games (2-3)
| Date | Opponent | Result | Score |
|---|---|---|---|
| Sep 20 | vs TB | L | 1-5 |
| Sep 19 | vs TB | L | 1-2 |
| Sep 18 | vs TB | W | 4-2 |
| Sep 17 | vs TEX | W | 4-3 |
| Sep 16 | vs TEX | L | 3-7 |
Guardians
Last 5 Games (5-0)
| Date | Opponent | Result | Score |
|---|---|---|---|
| Sep 20 | vs ATH | W | 1-0 |
| Sep 19 | vs ATH | W | 12-6 |
| Sep 18 | vs ATH | W | 5-3 |
| Sep 16 | vs CWS | W | 6-3 |
| Sep 15 | vs CWS | W | 7-6 |
Explore more MLB player prop predictions with PlayerProps.ai, or use our Prop Predictor tool to find today’s top edge picks.
Frequently Asked Questions
What are the best player prop bets for Red Sox vs Guardians?
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Our AI models are analyzing the latest data for this MLB matchup. For the most current player prop recommendations, check our Prop Predictor tool.
What time does Red Sox vs Guardians start?
The game is scheduled for 9/22/2026, 6:45:00 PM.
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