Pirates vs. Cardinals Prop Bets & AI Predictions (Sep 22, 2026)

Looking for expert MLB player prop predictions for Sep 22, 2026? Our AI breaks down the key data from the Pirates vs Cardinals matchup so you can make smarter picks today.

Pirates Preview:

These players have been hitting the ball well recently:

  • Brandon Lowe has gotten a hit in 9 of his last 10 games (hit his line in 90% of 10 games)
  • Rafael Flores has gotten a hit in 9 of his last 10 games (hit his line in 90% of 10 games)
  • Oneil Cruz has gotten a hit in 8 of his last 10 games (hit his line in 80% of 10 games)

The player with the highest projected chance at a Home Run is:

  • Rafael Flores has a 0.33 Home Run projection

Cardinals Preview:

These players have been hitting the ball well recently:

  • Nathan Church has gotten a hit in 8 of his last 10 games (hit his line in 80% of 10 games)
  • Alec Burleson has gotten a hit in 7 of his last 10 games (hit his line in 70% of 10 games)
  • JJ Wetherholt has gotten a hit in 6 of his last 10 games (hit his line in 60% of 10 games)

The player with the highest projected chance at a Home Run is:

  • Alec Burleson has a 0.11 Home Run projection

Roster Outlook

Pirates Cardinals
Projected Pitcher Projected Pitcher
Jared Jones Andre Pallante
Projected Roster Projected Roster
  • Konnor Griffin (SS)
  • Brandon Lowe (2B)
  • Bryan Reynolds (LF)
  • Oneil Cruz (CF)
  • Nick Gonzales (3B)
  • Ryan OHearn (DH)
  • Rafael Flores (C)
  • Spencer Horwitz (1B)
  • Jake Mangum (RF)
  • JJ Wetherholt (2B)
  • Ivan Herrera (DH)
  • Alec Burleson (1B)
  • Jordan Walker (RF)
  • Leo Bernal (C)
  • Bryan Torres (LF)
  • Thomas Saggese (3B)
  • Masyn Winn (SS)
  • Nathan Church (CF)

Pirates

Projected Pitcher
Jared Jones
Projected Roster
  • Konnor Griffin (SS)
  • Brandon Lowe (2B)
  • Bryan Reynolds (LF)
  • Oneil Cruz (CF)
  • Nick Gonzales (3B)
  • Ryan OHearn (DH)
  • Rafael Flores (C)
  • Spencer Horwitz (1B)
  • Jake Mangum (RF)

Cardinals

Projected Pitcher
Andre Pallante
Projected Roster
  • JJ Wetherholt (2B)
  • Ivan Herrera (DH)
  • Alec Burleson (1B)
  • Jordan Walker (RF)
  • Leo Bernal (C)
  • Bryan Torres (LF)
  • Thomas Saggese (3B)
  • Masyn Winn (SS)
  • Nathan Church (CF)

Recent Form

Pirates

Last 5 Games (4-1)

Date Opponent Result Score
Sep 20 vs KC W 4-3
Sep 19 vs KC W 6-5
Sep 18 vs KC W 8-5
Sep 17 vs MIL W 7-4
Sep 16 vs MIL L 4-5

Cardinals

Last 5 Games (1-4)

Date Opponent Result Score
Sep 20 vs WSH W 5-3
Sep 19 vs WSH L 5-8
Sep 18 vs WSH L 1-9
Sep 16 vs SF L 5-6
Sep 15 vs SF L 3-10

Explore more MLB player prop predictions with PlayerProps.ai, or use our Prop Predictor tool to find today’s top edge picks.

Frequently Asked Questions

What are the best player prop bets for Pirates vs Cardinals?

  • Our AI models are analyzing the latest data for this MLB matchup. For the most current player prop recommendations, check our Prop Predictor tool.

What time does Pirates vs Cardinals start?

The game is scheduled for 9/22/2026, 6:40:00 PM.

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  • NRFI tool – Specialized insights and predictions for “No Runs First Inning” bets.

More MLB Sep 22 Games

Looking for more MLB action? Check out our full MLB prop bets archive for every game, every day.

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